4-Aminopyridine → HCID 59539421, 화합물

HRID 1631819

반응식

HRID 1631819 반응식
[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]/[C:16]([OH:18])=O)=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1.[NH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.C1CCC(N=C=NC2CCCCC2)CC1>>[CH3:24][O:23][C:4]1[CH:3]=[C:2]([CH3:1])[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]/[C:16]([NH:25][C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)=[O:18])=[C:6]([CH3:21])[C:5]=1[CH3:22]

참가 물질

4

반응물 3

HCID 17274-AminopyridineHCID 10868DicyclohexylcarbodiimideHCID 5284513Acitretin

생성물 1

HCID 59539421HCID 59539421, 화합물수율 64.1%

실험 절차

Reaction of acitretin (0.10 g, 0.31 mmol) with 4-aminopyridine (0.03 g, 0.31 mmol) was conducted according to the general amide coupling procedure using DCC to obtain the product as a yellow solid (0.08 g, 61%). EIMS m/z: 403 ([M]+), 401 ([M]−).

출처 및 근거

ORD 기록
ord-acdacfca39aa425c93d75e8db238ecf4
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791275B2

연결된 노트

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