Methyl vinyl ketone → Spiro(4.5)dec-6-ene-8-one

HRID 1631850

반응식

HRID 1631850 반응식
[CH:1]1([CH:6]=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:8]([C:10]([CH3:12])=[O:11])=[CH2:9]>>[CH2:2]1[C:1]2([CH2:6][CH2:12][C:10](=[O:11])[CH:8]=[CH:9]2)[CH2:5][CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 6570Methyl vinyl ketoneHCID 70106Cyclopentanecarbaldehyde

생성물 1

HCID 139772Spiro(4.5)dec-6-ene-8-one수율 54%

실험 절차

Piperidine enamine was prepared by a method analogous to that described in Organic Syntheses, Collective Volume 7, p 473, using 221.84 g of cyclopentane carbaldehyde instead of cyclooctane carbaldehyde. Through Michael addition of piperidine enamine to methyl vinyl ketone, cyclization by aldol condensation, dehydration, hydrolysis, and vacuum distillation for purification, there was obtained 173.4 g (yield 54%) of spiro[4.5]dec-6-en-8-one.

후처리

  1. customby aldol condensation, dehydration, hydrolysis, and vacuum distillation
  2. customfor purification

출처 및 근거

ORD 기록
ord-c5f62ab611364ee3909ce0b58766bf29
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791288B2

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