ethyl 3-(3,5-dimethyl-1H-pyrazol-4-yl)propanoate → 3-[3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-propionic acid ethyl ester
반응식
CO[C:3](=O)[CH2:4][C:5]1[C:6]([CH3:21])=[N:7][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[C:9]=1[CH3:10].[CH2:23]([O:25][C:26](=[O:36])CCC1C(C)=NNC=1C)[CH3:24]>>[CH2:23]([O:25][C:26](=[O:36])[CH2:3][CH2:4][C:5]1[C:6]([CH3:21])=[N:7][N:8]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([N+:18]([O-:20])=[O:19])=[CH:16][CH:17]=2)[C:9]=1[CH3:10])[CH3:24]참가 물질
3
실험 절차
Intermediate 8.1.1 can be prepared according to the method described for intermediate 1.1.2, employing in the alkylation reaction 3-(3,5-dimethyl-1H-pyrazol-4-yl)-propionic acid ethyl ester (Akos, MFCD03834497) instead of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester.
출처 및 근거
- ORD 기록
- ord-772c55c142eb4f0b845c8587def888ab
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08791272B2
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