Potassium Carbonate → HCID 58020135, 화합물

HRID 1632086노트

반응식

HRID 1632086 반응식
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9]Br)[CH:5]=[CH:4][C:3]=1[O:11][CH3:12].[OH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1.C([O-])([O-])=O.[K+].[K+]>COCCOC>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][N:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]2=[O:13])[CH:5]=[CH:4][C:3]=1[O:11][CH3:12]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 58020164860584-79-8HCID 178516071HCID 178516071, 화합물

생성물 1

HCID 58020135HCID 58020135, 화합물수율 40%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

반응 조건

온도
80 °C

실험 절차

Into a 100 mL round bottom flask was added 2-bromo-4-(2-bromo-ethyl)-1-methoxy-benzene (I-165, 1.82 g, crude), 2-hydroxypyridine (258 mg, 2.72 mmol), K2CO3 (625 mg, 4.53 mmol), and DME (20 mL). After stirring for 18 hours at 80° C. the suspension was filtered and the filtrate was concentrated. The residue was purified by flash column chromatography eluting with 25-50% acetone/hexanes to afford 221 mg of I-166 as a brown oil in 40% yield (2 steps).

후처리

  1. filtrationwas filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by flash column chromatography
  4. washeluting with 25-50% acetone/hexanes
  5. customto afford 221 mg of I-166 as a brown oil in 40% yield (2 steps)

출처 및 근거

ORD 기록
ord-fbce92b0c78d42c8b73f6cbf18468173
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791267B2

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