Triethylamine → HCID 131713841, 화합물

HRID 1632390노트

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HRID 1632390 반응식
[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[C@H:2]([C:7]([O:9]N1C(=O)CCC1=O)=O)[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:27][C@H:28]([C:33]([NH:35][C@H:36]([C:41]([NH:43][C@H:44]([C:49]([NH:51][C@H:52]([C:54]([NH:56][C@H:57]([C:63]([OH:65])=[O:64])[CH2:58][CH2:59][C:60](=[O:62])[NH2:61])=[O:55])[CH3:53])=[O:50])[CH2:45][CH:46]([CH3:48])[CH3:47])=[O:42])[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30].C(N(CC)CC)C>CN(C)C=O>[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:18])[C@H:2]([C:7]([NH:27][C@H:28]([C:33]([NH:35][C@H:36]([C:41]([NH:43][C@H:44]([C:49]([NH:51][C@H:52]([C:54]([NH:56][C@H:57]([C:63]([OH:65])=[O:64])[CH2:58][CH2:59][C:60](=[O:62])[NH2:61])=[O:55])[CH3:53])=[O:50])[CH2:45][CH:46]([CH3:47])[CH3:48])=[O:42])[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30])=[O:9])[CH2:3][CH:4]([CH3:5])[CH3:6]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 11089751N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl esterHCID 131713840HCID 131713840, 화합물

생성물 1

HCID 131713841HCID 131713841, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.69 Gram of Z-Leu-OSu, the above-obtained H-Ile-Leu-Leu-Ala-Gln-OH and 0.22 ml of triethylamine were dissolved in 50 ml of dimethylformamide, and the mixture was stirred at a room temperature for 20 hours. After removal of dimethylformamide by distillation, 1N-succinic acid was added to the residue, the precipitated material was collected by filtration and washed with water until the filtrate become neutral and then dried. The dried material was washed with hot methanol to obtain 1.10 g of Z-Leu-Ile-Leu-Leu-Ala-Gln-OH.

후처리

  1. customAfter removal of dimethylformamide
  2. distillationby distillation, 1N-succinic acid
  3. additionwas added to the residue
  4. filtrationthe precipitated material was collected by filtration
  5. washwashed with water until the filtrate
  6. customdried
  7. washThe dried material was washed with hot methanol

출처 및 근거

ORD 기록
ord-94b1f016736a46f2b9bddeabdbb81f28
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04474754

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