2-Amino-4,6-dimethoxypyrimidine → 2-(1,2,3-Thiadiazol-4-yl)phenyl N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]sulfamate

HRID 1632442노트

반응식

HRID 1632442 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[N:12]([S:15]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]1[N:26]=[N:27][S:28][CH:29]=1)(=[O:17])=[O:16])=[C:13]=[O:14]>O1CCCC1>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:13]([NH:12][S:15](=[O:17])(=[O:16])[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]2[N:26]=[N:27][S:28][CH:29]=2)=[O:14])[N:7]=1

참가 물질

4

반응물 2

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 203987932-(1,2,3-Thiadiazol-4-yl)phenyl isocyanatosulfonate

생성물 1

HCID 133744032-(1,2,3-Thiadiazol-4-yl)phenyl N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]sulfamate수율 26.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
25 °C

실험 절차

By the procedure of Example 4, 5.3 g of 2-amino-4,6-dimethoxypyrimidine in 20 ml of tetrahydrofuran was reacted with 14 g of the isocyanate prepared in Example 5 above in 30 ml of tetrahydrofuran. After stirring the mixture at 25° C. for 3 hours, the mixture was filtered and the solid isolated was recrystallized from acetonitrile to yield 4 g of the title compound; m.p. 173°-175° C.

후처리

  1. filtrationthe mixture was filtered
  2. customthe solid isolated
  3. customwas recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-f959ab465c404f92b54ba9e6c4d0474e
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04475944

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