Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3,4,5-Trihydroxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Gallic Acid | HCID 370 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Phosphorus trichloride | HCID 24387 | — |
| 반응물 | Benzoic acid, 3,4,5-tris(acetyloxy)- | HCID 95088 | — |
| 반응물 | 3,4,5-Triacetoxybenzoyl chloride | HCID 155506 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3,4,5-Trihydroxybenzamide | HCID 69256 | — |
반응 단계
Namely, gallic acid is converted into 3,4,5-triacetoxybenzoic acid by reacting with acetic anhydride or acetic acid chloride in the presence of a base such as NaOH (J. Chem. Soc., 2495 (1931)), Na2CO3, pyridine or so on and, further, converted into the corresponding acid chloride by reacting with thionyl chloride or phosphorus trichloride. The thus-obtained 3,4,5-triacetoxybenzoic acid chloride was made to react with an appropriate amine in the presence of a base such as pyridine, triethylamine or the like. Thereafter, the reaction product is treated with sodium acetate, sodium hydroxide or hydrochloric acid in methanol or ethanol to produce an intended gallic acid amide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04476219 |
| 출처 데이터셋 | uspto-grants-1984_10 |
| ORD ID | ord-cdde5cb78ea24ee3b3a1e264077d2e68 |
| 출처 메모 | uspto-grants-1984_10 |