Diethyl Ether → 1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one

HRID 1632668노트

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][CH:4]=1.CC[O:20]CC>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][C:10]2=[O:20])=[CH:7][CH:8]=1

참가 물질

반응물 2

HCID 3283Diethyl Ether

HCID 7757151-(4-methoxyphenyl)-1H-indole

생성물 1

HCID 133395441-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one

실험 절차

Omitting the final chromatography, but triturating the crude product three times with ether, 1-(4-methoxyphenyl)indole (18.1 g, 81 mmoles) was converted to title product, 12.0 g, m.p. 115°-117° C., pnmr/CDCl3 /TMS/delta: 3.65 (s, 2H), 3.8 (s, 3H), 6.6-7.4 (m, 8H).

출처 및 근거

ORD 기록: ord-09f9c527b29f49ca90ac33a6fc010a0a
출처 데이터셋: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04476307

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