Ammonium Hydroxide → S-o-nitrophenyl-L-cysteine

HRID 1632768노트

반응식

HRID 1632768 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][CH2:11][C@@H:12]([C:17]([OH:19])=[O:18])[NH:13]C(=O)C)([O-:3])=[O:2].[OH-].[NH4+]>S(=O)(=O)(O)O.O>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][CH2:11][C@@H:12]([C:17]([OH:19])=[O:18])[NH2:13])([O-:3])=[O:2]

참가 물질

5

반응물 2

HCID 14923Ammonium HydroxideHCID 185068L-Cysteine, N-acetyl-S-(2-nitrophenyl)-

생성물 1

HCID 124713S-o-nitrophenyl-L-cysteine

시약·촉매·용매 2

HCID 962Water용매HCID 1118Sulfuric Acid용매

실험 절차

A solution of 71 g of S-(o-nitrophenyl)-N-acetyl-L-cysteine in 300 ml of 18M sulfuric acid and 1200 ml of water is heated to reflux for 30 min. The solution is cooled in ice and treated with 700 ml of concentrated ammonium hydroxide. The resulting solid is recrystallized from boiling water to afford S-(o-nitrophenyl)-L-cysteine; m.p. 168°-171° C.; [α]D =+67.3° (c=1.1, 1N hydrochloric acid).

후처리

  1. temperatureto reflux for 30 min
  2. temperatureThe solution is cooled in ice
  3. customThe resulting solid is recrystallized

출처 및 근거

ORD 기록
ord-aec0a29497ac4592b79b9a5c838332be
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04477464

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