Thionyl Chloride → HCID 178447911, 화합물

HRID 1632916

반응식

HRID 1632916 반응식
O=S(Cl)Cl.[CH2:5]([O:7][C:8]1[CH:16]=[CH:15][C:14]([C@H:17]2[CH2:22][CH2:21][C@H:20]([CH2:23][CH2:24][CH3:25])[CH2:19][CH2:18]2)=[CH:13][C:9]=1[C:10](N)=[O:11])[CH3:6].OC1C=CC([C@H]2CC[C@H](CCC)CC2)=CC=1.C(Cl)(Cl)Cl.[OH-].[K+]>>[CH2:5]([O:7][C:8]1[CH:16]=[CH:15][C:14]([C@H:17]2[CH2:18][CH2:19][C@H:20]([CH2:23][CH2:24][CH3:25])[CH2:21][CH2:22]2)=[CH:13][C:9]=1[CH:10]=[O:11])[CH3:6]

참가 물질

5

반응물 4

HCID 24386Thionyl ChlorideHCID 19913595chloroform KOHHCID 178447901HCID 178447901, 화합물HCID 178447909HCID 178447909, 화합물

생성물 1

HCID 178447911HCID 178447911, 화합물

실험 절차

18 g of SOCl2 is added, at 80°, to a suspension of 28.9 g of 2-ethoxy-5-(trans-4-propyl-cyclohexyl)-benzamide [obtainable, for example, by reaction of trans-1-(4-hydroxyphenyl)-4-propyl-cyclohexane with chloroform/KOH to give 2-ethoxy-5-(trans-4-propylcyclohexyl)-benzaldehyde, oxidation to the acid, reaction with SOCl2 to give the chloride and reaction with NH3 ] in 100 ml of toluene. After the mixture has been stirred at 80° for 6 hours, cooled and poured into water, 2-ethoxy-5-(trans-4-propyl-cyclohexyl)-benzonitrile of m.p. 32° is obtained.

출처 및 근거

ORD 기록
ord-73f95f4c04d84b6a8a84c1a74d8a2353
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04478740

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