Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

HRID 1632979

반응식

HRID 1632979 반응식
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 732736-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 3129536-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, and was then separated by filtration and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.

후처리

  1. customto react overnight in a sealed bomb at about 20° C
  2. customwas then separated by filtration
  3. washwashed sequentially with water and methanol

출처 및 근거

ORD 기록
ord-5adf28619ccd4cc8b37519390f821a69
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04478835

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