Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione
반응식
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1참가 물질
4
실험 절차
A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, and was then separated by filtration and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.
후처리
- customto react overnight in a sealed bomb at about 20° C
- customwas then separated by filtration
- washwashed sequentially with water and methanol
출처 및 근거
- ORD 기록
- ord-5adf28619ccd4cc8b37519390f821a69
- 출처 데이터셋
- uspto-grants-1984_10
- 특허 번호
- US04478835
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