Potassium Carbonate → 4-(Phenylsulfamoyl)phenyl 4-ethenylbenzoate

HRID 1633163노트

반응식

HRID 1633163 반응식
Br[CH2:2][CH2:3][C:4]1[CH:28]=[CH:27][C:7]([C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([S:17](=[O:26])(=[O:25])[NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:13][CH:12]=2)=[O:9])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH:3]([C:4]1[CH:28]=[CH:27][C:7]([C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([S:17](=[O:25])(=[O:26])[NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:13][CH:12]=2)=[O:9])=[CH:6][CH:5]=1)=[CH2:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 204418094-(Phenylsulfamoyl)phenyl 4-(2-bromoethyl)benzoate

생성물 1

HCID 204418184-(Phenylsulfamoyl)phenyl 4-ethenylbenzoate수율 76.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 18.5 g (0.0402 mol) of 4-(N-phenylsulfamoyl)phenyl 4-(2-bromoethyl)benzoate, 5.55 g (0.0402 mol) of potassium carbonate and 250 ml of acetone was stirred at room temperature for approximately 48 hours. The mixture was filtered and concentrated to an oily solid. Recrystallization from ethanol:water gave 11.7 g (76.7% of theory) of 4-(N-phenylsulfamoyl)phenyl 4-vinylbenzoate; mp=59°-60° C.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated to an oily solid
  3. customRecrystallization from ethanol

출처 및 근거

ORD 기록
ord-d8a37e776cf24f558a0f0ecd6e81495c
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04478992

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