Thionyl Chloride → (4-Fluorophenoxy)acetyl chloride
반응식
[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8](O)=[O:9])=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([Cl:15])=[O:9])=[CH:4][CH:3]=1참가 물질
4
실험 절차
Into a 100 ml round bottom flask equipped with a magnetic stirrer, reflux condenser equipped with a connector to a 50% sodium hydroxide trap, 6.81 g (0.040 mole) para-fluorophenoxyacetic acid (the product of Example 2), 2.96 ml (0.044 mole) thionyl chloride, and about 40 ml toluene. The reaction mixture was stirred at reflux for two hours, allowed to cool to room temperature, and then concentrated to give 7.2 g of the product, a brwon liquid.
후처리
- customInto a 100 ml round bottom flask equipped with a magnetic stirrer
- temperaturereflux condenser
- customequipped with a connector to a 50% sodium hydroxide trap
- temperatureat reflux for two hours
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-8c2280aef46a4fe7ab60c4afd38eef12
- 출처 데이터셋
- uspto-grants-1984_10
- 특허 번호
- US04479900
반응 노트
불러오는 중…