Lumazine → 3-Amino-5,6-dichloropyrazine-2-carbaldehyde

HRID 1633237

반응식

[NH2:1][C:2]1[C:7]([C:8](OC)=[O:9])=[N:6][C:5]([Cl:12])=[C:4]([Cl:13])[N:3]=1.NC1C(C(OC)=O)=NC=CN=1.C1N=C2C(NC(NC2=NC=1)=O)=O>>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:12])=[C:4]([Cl:13])[N:3]=1

참가 물질

반응물 3

HCID 10250Lumazine

HCID 72669Methyl 3-aminopyrazinecarboxylate

HCID 73828Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate2회

생성물 1

HCID 133678713-Amino-5,6-dichloropyrazine-2-carbaldehyde

실험 절차

The 2-amino-5,6-dichloro-3-(methoxycarbonyl)pyrazine (also named methyl 3-amino-5,6-dichloropyrazinecarboxylate) may be prepared by a method described in J. Med. Chem. 10, 66 (1967), from 2-amino-3-carbomethoxypyrazine, reported in J. Am. Chem. Soc. 67, 1711 (1945), which in turn is prepared from lumazine whose preparation from readily available materials is reported in J. Am. Chem. Soc. 67, 802 (1945).

출처 및 근거

ORD 기록: ord-177d836925c84387a85e5eded9c21c13
출처 데이터셋: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04479953

연결된 노트

불러오는 중…