Ethyl 4-chloro-1,6-naphthyridine-3-carboxylate → Ethyl 4-[2-(4-pyridyl)hydrazino]-1,6-naphthyridine-3-carboxylate hydrochloride
반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[N:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].Cl.[NH:18]([C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)[NH2:19]>CO>[ClH:1].[N:23]1[CH:24]=[CH:25][C:20]([NH:18][NH:19][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[N:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:21][CH:22]=1참가 물질
4
실험 절차
A solution of 2.36 g of ethyl 4-chloro-1,6-naphthyridine-3-carboxylate and 1.53 g of 4-hydrazinopyridine hydrochloride in 37 ml of methanol is stirred for 19 hours at room temperature, then refluxed for 4 hours. The reaction mixture is then cooled in an ice bath, and solid is collected by filtration, washed successively with methanol and ether to yield ethyl 4-[2-(4-pyridyl)hydrazino]-1,6-naphthyridine-3-carboxylate hydrochloride.