1,3-Dibromopropane → 5-(3-Bromo-propoxy)-1-(4-fluoro-phenyl)-1H-indole

HRID 1633621노트

반응식

HRID 1633621 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH:10]=[CH:9]2)=[CH:4][CH:3]=1.[Br:18][CH2:19][CH2:20][CH2:21]Br>>[Br:18][CH2:19][CH2:20][CH2:21][O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH:9]=[CH:10]2

참가 물질

3

반응물 2

HCID 80011,3-DibromopropaneHCID 114815561-(4-Fluoro-phenyl)-1H-indol-5-ol

생성물 1

HCID 186794645-(3-Bromo-propoxy)-1-(4-fluoro-phenyl)-1H-indole

실험 절차

In analogy to example 3.1, 1-(4-Fluoro-phenyl)-1H-indol-5-ol and 1,3-dibromopropane were converted to yield 5-(3-Bromo-propoxy)-1-(4-fluoro-phenyl)-1H-indole as colorless solid 61-62° C., MS: 347 (M, 1Br).

출처 및 근거

ORD 기록
ord-dbf6649fbf65455cbb93b82da81e765c
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06503907B2

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