Potassium Carbonate → HCID 18679523, 화합물

HRID 1633664노트

반응식

HRID 1633664 반응식
C[Si]([C:5]#[C:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:21]3[C:16](=[CH:17][C:18]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)=[CH:9][CH:8]=1)(C)C.C([O-])([O-])=O.[K+].[K+]>CO>[C:6]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:21]3[C:16](=[CH:17][C:18]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)=[CH:9][CH:8]=1)#[CH:5]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 186794765-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol

생성물 1

HCID 18679523HCID 18679523, 화합물수율 87.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

970 mg (2.6 mmol) 5-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol in 10 ml MeOH were treated with 41.4 mg (3 mmol) K2CO3. The solution was concentrated, the residue dissolved in ether and 0.5M HCl and the organic phase was washed with water and dried over Na2SO4. Column chromatography on silica gel with ether yielded 680 mg (87%) 5-[1-(4-Ethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol as orange oil, MS: 299 (M).

후처리

  1. concentrationThe solution was concentrated
  2. dissolutionthe residue dissolved in ether
  3. wash0.5M HCl and the organic phase was washed with water
  4. dry with materialdried over Na2SO4

출처 및 근거

ORD 기록
ord-d865e9172b944a3db7eca46594e8f725
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06503907B2

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