4-Fluoroiodobenzene → HCID 18679484, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][CH:6]=[CH:5]2.[F:12][C:13]1[CH:18]=[CH:17][C:16](I)=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[N:7]([C:16]1[CH:17]=[CH:18][C:13]([F:12])=[CH:14][CH:15]=1)[CH:6]=[CH:5]2

참가 물질

반응물 2

HCID 96054-Fluoroiodobenzene

HCID 116871455-bromo-6-fluoro-1H-indole

생성물 1

HCID 18679484HCID 18679484, 화합물

실험 절차

In analogy to example 23.3, 5-Bromo-6-fluoro-1H-indole and 1-fluoro-4-iodobenzene were converted to yield 5-Bromo-1-(4-fluoro-phenyl)-6-fluoro-1H-indole as a light yellow solid, MS: 307 (M, 1Br).

출처 및 근거

ORD 기록: ord-536b51ea960543d4a006d1f40ae38016
출처 데이터셋: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06503907B2

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