Acetic Acid → 2-[1-(4-Chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one

HRID 1633802노트

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HRID 1633802 반응식
C(O)(=[O:3])C.S(=O)(=O)(O)O.O.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([CH3:29])[C:19]([NH:21][C:22]([C:27]#N)([CH3:26])[CH:23]([CH3:25])[CH3:24])=[O:20])=[CH:14][CH:13]=1>C(OCC)(=O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([C:19]2[O:20][C:26](=[O:3])[C:22]([CH:23]([CH3:25])[CH3:24])([CH3:27])[N:21]=2)[CH3:29])=[CH:14][CH:13]=1

참가 물질

6

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HCID 176Acetic AcidHCID 962Water2회HCID 1118Sulfuric AcidHCID 186801792-(4-chlorophenyl)-N-(1-cyano-1,2-dimethylpropyl)propanamide

생성물 1

HCID 113120132-[1-(4-Chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one수율 100%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

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온도
60 °C

실험 절차

40 ml of glacial acetic acid, 1.96 g (0.019 mole) of concentrated sulfuric acid and 0.36 g (0.02 mole) of water were added to 5.56 g (0.02 mole) of 2-(4-chlorophenyl)-N-(1-cyano-1,2-dimethylpropyl)propanamide. The mixture was stirred at 60° C. for 2 hours to give rise to a reaction. After the completion of the reaction, the reaction mixture was cooled. Thereto were added 400 ml of water and 400 ml of ethyl acetate for layer separation. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution, and concentrated to obtain 5.58 g of 2-[1-(4-chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one (yield=100%).

후처리

  1. customto give rise
  2. customto a reaction
  3. customAfter the completion of the reaction
  4. temperaturethe reaction mixture was cooled
  5. customfor layer separation
  6. washThe organic layer was washed with a saturated aqueous sodium bicarbonate solution
  7. concentrationa saturated aqueous sodium chloride solution, and concentrated

출처 및 근거

ORD 기록
ord-ec339a86d8a94b1886f1c1ed8e8d1474
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06504046B1

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