Potassium Hydroxide → 6-(Methoxycarbonyl)naphthalene-2-carboxylic acid

HRID 1633863

반응식

HRID 1633863 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:15]([O:17]C)=[O:16].[OH-].[K+]>O1CCOCC1.CO>[CH3:14][O:13][C:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[C:2]([C:15]([OH:17])=[O:16])[CH:3]=[CH:4]2)=[O:12]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 61225Dimethyl-2,6-naphthalenedicarboxylate

생성물 1

HCID 33802176-(Methoxycarbonyl)naphthalene-2-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

반응 조건

온도
70 °C

실험 절차

A solution of dimethyl 2,6-naphthalenedicarboxylate (39.6 g, 162 mmol) in dioxane (1.2 L) was heated to 70-80° C., slowly treated with a solution of KOH (9.1 g, 162 mmol) in methanol (162 mL), heated to 70° C., stirred for 30 minutes, cooled to room temperature, and filtered. The solid was washed sequentially with dioxane and diethyl ether, dissolved in water, adjusted to pH<7 with 1M HCl, and filtered. The solid was washed with water and dried to provide the desired product.

후처리

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. washThe solid was washed sequentially with dioxane and diethyl ether
  4. dissolutiondissolved in water
  5. filtrationfiltered
  6. washThe solid was washed with water
  7. customdried

출처 및 근거

ORD 기록
ord-0692141528424371891d9b7224ec0429
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06504031B1

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