Dimethylamine → N,N-Dimethyl 3-nitrobenzenesulfonamide

HRID 1633918

반응식

HRID 1633918 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([S:10](Cl)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:14][NH:15][CH3:16]>C1COCC1>[CH3:14][N:15]([CH3:16])[S:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:12])=[O:11]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 84763-Nitrobenzenesulfonyl chloride

생성물 1

HCID 224495N,N-Dimethyl 3-nitrobenzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

3-Nitrobenzenesulfonyl chloride (22.8 mmol, 5.05 g) was dissolved in dry THF (50 mL). Dimethylamine in THF (2M, 34 mL) was added and the mixture was refluxed for 2 hours. Upon cooling, the mixture was filtered and the filtrate was evaporated in vacuo. The residue was dissolved in ethyl acetate (250 mL), washed with water (3×50 mL) and dried over MgSO4. Evaporation of the solvent afforded the title compound.

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureUpon cooling
  3. filtrationthe mixture was filtered
  4. customthe filtrate was evaporated in vacuo
  5. dissolutionThe residue was dissolved in ethyl acetate (250 mL)
  6. washwashed with water (3×50 mL)
  7. dry with materialdried over MgSO4
  8. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-3371dc23fafb4b658677b97423ae6551
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06503949B1

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