6-(3-Cyanopropyloxy)nicotinic acid, methyl ester → 6-(3-Cyanopropyloxy)nicotinic acid
반응식
[C:1]([CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][N:8]=1)#[N:2]>CO.O>[C:1]([CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=1)#[N:2]참가 물질
3
실험 절차
6-(3-cyanopropyloxy)nicotinic acid, methyl ester (1.8 mmol) was dissolved in methanol/water (16 mL:4 mL) and treated with LiOH monohydrate (2.7 mmol). After stirring overnight, volatiles were removed and reaction neutralized with 1N sulfuric acid. The solid product was collected by filtration, washed with water and dried to give 6-(3-cyanopropyloxy)nicotinic acid (315 mg, 85%).
후처리
- customvolatiles were removed
- customreaction neutralized with 1N sulfuric acid
- filtrationThe solid product was collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-b2e80849fd214f5b823e02b009c219d4
- 출처 데이터셋
- uspto-grants-2003_01
- 특허 번호
- US06506747B1
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