Dimethylformamide → 4-Cyano-2-methoxybenzoyl chloride

HRID 1634132노트

반응식

HRID 1634132 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:17])=O.CN(C=O)C>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:4]=1[C:5]([Cl:17])=[O:6]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 151660044-Cyano-2-methoxybenzoic acid

생성물 1

HCID 226750494-Cyano-2-methoxybenzoyl chloride수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Methoxy-4-cyanobenzoic acid (Tetrahedron Letters, 1986, 27(49), 5997-6000) (1 g, 5.6 mmol) was dissolved in CH2Cl2 (20 ml). Oxalyl chloride (1.5 ml, 8.2 mmol) was rapidly introduced into the solution and a drop of DMF was added. A vigorous reaction took place with the abundant evolution of gaseous products. The solution was stirred for 1 h then allowed to stand over night. Solvent was removed using a rotary evaporator to leave 1.1 g of an off white solid (5.6 mmol, yield 99%) that was used without further purification.

후처리

  1. customA vigorous reaction
  2. waitto stand over night
  3. customSolvent was removed
  4. customa rotary evaporator

출처 및 근거

ORD 기록
ord-5495fe1d9f934bc79177f6ce1936184c
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506758B2

반응 노트

불러오는 중…