3,5-Difluorophenylacetic acid → (S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline

HRID 1634393

반응식

HRID 1634393 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[NH2:14][CH:15]([C:17]1[S:18][CH2:19][C@H:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:21]=1)[CH3:16]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:14][CH:15]([C:17]2[S:18][CH2:19][C@H:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:21]=2)[CH3:16])=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1

참가 물질

3

반응물 2

HCID 1454243,5-Difluorophenylacetic acidHCID 69741166(S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride

생성물 1

HCID 69743302(S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline

실험 절차

Following General Procedure A above and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride (Example G), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.2 in 1:1 EtOAc/hexanes) and the product was purified by silica gel chromatography using 1:1 EtOAc/hexanes as the eluant.

후처리

  1. customthe product was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-b411694722a74e369ea9144f29e88c4b
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506782B1

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