HCID 18678579, 화합물 → 4-(2-Hydroxy-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propoxy)-fluoren-9-one
반응식
[O:1]1[CH2:3][C@H:2]1[CH2:4][O:5][C:6]1[C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]=2[CH:9]=[CH:8][CH:7]=1.[NH2:20][CH2:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][C:30]([F:33])([F:32])[F:31])[CH2:24][CH2:23]1>>[OH:1][CH:2]([CH2:3][NH:20][CH2:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][C:30]([F:33])([F:31])[F:32])[CH2:24][CH2:23]1)[CH2:4][O:5][C:6]1[C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]=2[CH:9]=[CH:8][CH:7]=1참가 물질
3
실험 절차
Prepared from 4-[(2S)-oxiranylmethoxy]-9-fluorenone (0.087 g, 0.34 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.126 g, 0.6 mmol) of according to the procedure used for Example 2 to give 0.092 g of the title compound as a yellow solid.
출처 및 근거
- ORD 기록
- ord-9ddd617a27c6485d99d7ddd9553594df
- 출처 데이터셋
- uspto-grants-2003_01