Chlorosulfonic acid → 4-(3-Methyl-2-oxo-1-imidazolidinyl)benzenesulfonyl chloride

HRID 1634825노트

반응식

HRID 1634825 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]1=[O:13].[Cl:14][S:15](O)(=[O:17])=[O:16]>>[CH3:1][N:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([S:15]([Cl:14])(=[O:17])=[O:16])=[CH:9][CH:8]=2)[C:3]1=[O:13]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 197983301,3-Dihydro-1-methyl-3-phenyl-2H-imidazol-2-one

생성물 1

HCID 186784164-(3-Methyl-2-oxo-1-imidazolidinyl)benzenesulfonyl chloride

실험 절차

A solution of 1-methyl-3-phenylimidazol-2-one (5.7 g, 32.3 mmol) in 10 mL of chlorosulfonic acid was stirred at ambient temperature for 30 minutes. The reaction mixture was poured into ice/water and extracted with ethyl acetate. The organic phase was separated, dried (Na2SO4) and concentrated in vacuo to a white solid (7.4 g). Used as is in the following prep.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic phase was separated
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo to a white solid (7.4 g)

출처 및 근거

ORD 기록
ord-f32be6f8ac794ae786cde1bc3dc3445f
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506901B2

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