4-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)pyridine → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboaldehyde

HRID 1634894노트

반응식

HRID 1634894 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[CH:4]=1>C1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([C:5]2[CH:4]=[C:3]([CH:2]=[O:1])[CH:8]=[CH:7][N:6]=2)[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]

참가 물질

4

반응물 1

HCID 161259364-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)pyridine

생성물 1

HCID 186750102-(3,4,5-Trimethoxyphenyl)pyridine-4-carboaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매2회HCID 241Benzene용매

실험 절차

4-Hydroxymethyl-2-(3,4,5-Trimethoxyphenyl)pyridine (1.01 g) was dissolved in benzene (10 mL), and to the solution activated manganese dioxide (purity: 85%, 3.78 g) was added. The mixture was stirred at room temperature for 5 hours, and activated manganese dioxide (purity: 85%, 3.78 g) was additionally added. The mixture was stirred overnight. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1) to obtain the title compound.

후처리

  1. additionwas added
  2. stirringThe mixture was stirred overnight
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1)

출처 및 근거

ORD 기록
ord-9b766fb091704174bc69a6d4a7d607b2
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509329B1

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