Methanol → (4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

HRID 16350노트

반응식

HRID 16350 반응식
CO.[F:3][C:4]1[CH:5]=[C:6]([C@@H:12]2[CH2:17][O:16][CH2:15][C@@H:14]3[CH:18]=[CH:19][CH2:20][C:21](=[O:22])[N:13]23)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>[H][H].[Pt]=O>[F:3][C:4]1[CH:5]=[C:6]([C@@H:12]2[CH2:17][O:16][CH2:15][C@@H:14]3[CH2:18][CH2:19][CH2:20][C:21](=[O:22])[N:13]23)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]

참가 물질

5

반응물 2

HCID 887MethanolHCID 67464206(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one

생성물 1

HCID 44124045(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one수율 100.1%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 178418361HCID 178418361, 화합물용매

실험 절차

Platinum oxide (20.1 mg) was added to a methanol solution (6 mL) of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg). The resulting reaction solution was stirred at room temperature for 2 hr in hydrogen atmosphere and then filtered through Celite. The filtrate was concentrated under reduced pressure to give 252 mg of the title compound. The physical property values of this compound were as follows:

후처리

  1. customThe resulting reaction solution
  2. filtrationfiltered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-35f06373a37f4b7c9cbccb1f649396bd
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737141B2

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