p-Toluenesulfonic acid → Methyl 2-hydroxy-3-(2-(N-propyl-N-benzenesulfonylamino)ethoxy)-3,3-diphenylpropionate

HRID 1635081노트

반응식

HRID 1635081 반응식
[CH2:1]([N:4]([CH2:14][CH2:15][OH:16])[S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:7])=[O:6])[CH2:2][CH3:3].[O:17]1[C:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:18]1[C:19]([O:21][CH3:22])=[O:20].C1(C)C=CC(S(O)(=O)=O)=CC=1>C(Cl)Cl>[OH:17][CH:18]([C:23]([O:16][CH2:15][CH2:14][N:4]([CH2:1][CH2:2][CH3:3])[S:5]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)(=[O:7])=[O:6])([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:19]([O:21][CH3:22])=[O:20]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 10587027Methyl 3,3-diphenyloxirane-2-carboxylateHCID 18675618N-Propyl-N-(2-hydroxyethyl)benzenesulfonamide

생성물 1

HCID 18675641Methyl 2-hydroxy-3-(2-(N-propyl-N-benzenesulfonylamino)ethoxy)-3,3-diphenylpropionate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

7.3 g (30 mmol) of N-propyl-N-(2-hydroxyethyl)benzenesulfonamide and 7.6 g (30 mmol) of methyl 2,3-epoxy-3,3-diphenylpropionate were dissolved in 40 ml of methylene chloride and, with ice-cooling, 0.57 g (3 mmol) of p-toluenesulfonic acid was added. The reaction mixture was stirred at room temperature for 24 hours and then diluted with methylene chloride and extracted with 2M aqueous sodium hydroxide solution, the organic phase was separated off and dried over sodium sulfate and the solvent was distilled off. The residue (12.0 g of an oil) was directly reacted further.

후처리

  1. temperaturecooling
  2. extractionextracted with 2M aqueous sodium hydroxide solution
  3. customthe organic phase was separated off
  4. dry with materialdried over sodium sulfate
  5. distillationthe solvent was distilled off
  6. customThe residue (12.0 g of an oil) was directly reacted further

출처 및 근거

ORD 기록
ord-6d094d9e34f94aa0bd41ec1c7dc14af6
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509341B1

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