Diethyl Ether → 2-Propyl-4-chloro-3-methyl-pyridine

HRID 1635093노트

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HRID 1635093 반응식
[CH2:1](I)[CH2:2][CH3:3].[Li].[Cl:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][C:8]=1[CH3:13].CCOCC>C1COCC1.CCCCCC.C(OCC)(=O)C>[CH2:1]([C:9]1[C:8]([CH3:13])=[C:7]([Cl:6])[CH:12]=[CH:11][N:10]=1)[CH2:2][CH3:3]

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 336431-IodopropaneHCID 27577094-Chloro-3-methylpyridineHCID 3028194Lithium2회

생성물 1

HCID 186758642-Propyl-4-chloro-3-methyl-pyridine

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 21226206Ethyl acetate hexane용매

반응 조건

온도
40 °C

실험 절차

To a solution of propyl iodide (12.7 g) in THF (10 ml) is added lithium (0.45 g) and the reaction is allowed to stir at room temperature until complete dissolution of the lithium. 4-Chloro-3-methyl-pyridine (9.5 g) is then added and the mixture allowed to stir at 40° C. for 4 hours. After cooling at room temperature, ether is added and the organic phase washed with water. After removal of the solvent the desired product is obtained by chromatography using hexane/ether 9/1 as solvent.

후처리

  1. temperatureAfter cooling at room temperature
  2. washthe organic phase washed with water
  3. customAfter removal of the solvent the desired product
  4. customis obtained by chromatography

출처 및 근거

ORD 기록
ord-9b2234da1006484a9b09cfdc7d89fb83
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509349B1

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