Ethyl 2-cyanopyridine-4-carboxylate → 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester
반응식
C(O[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[CH:6]=1)C.[C:14]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])(=[O:16])[CH3:15].[Li]>>[C:18]([O:17][C:14](=[O:16])[CH2:15][C:4]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[CH:6]=1)=[O:13])([CH3:21])([CH3:20])[CH3:19]참가 물질
3
실험 절차
Prepared from 2-cyano-isonicotinic acid ethyl ester [CAS-No. 58481-14-4] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a light brown solid (7.70 g).
출처 및 근거
- ORD 기록
- ord-83699436881c4bada1739d2074f5b40f
- 출처 데이터셋
- uspto-grants-2003_01
- 특허 번호
- US06509328B1
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