Water → Methyl 2-methoxyisonicotinate

HRID 1635490노트

반응식

HRID 1635490 반응식
Cl[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH3:12][O-:13].[Na+].O>O1CCOCC1>[CH3:12][O:13][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=1)[C:5]([O:7][CH3:8])=[O:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 2736842Methyl 2-chloropyridine-4-carboxylateHCID 10942334Sodium Methoxide

생성물 1

HCID 14223465Methyl 2-methoxyisonicotinate수율 75%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of methyl 2-chloroisonicotinate (5.23 g, 0.030 mol) and sodium methoxide (2.47 g, 0.045 mol) in 15 mL of dioxane was heated at reflux for 1.5 hours. After the reaction mixture was cooled, water was added and the resulting mixture was extracted with methylene chloride. The organic layer was washed with brine, dried over magnesium sulfate and filtered. The filtrate was concentrated in vacuo to give 3.76 g (75%) of product as a yellow oil: Anal. Calc'd. for C8H9NO3: C, 57.48; H, 5.43; N, 8.38. Found: C, 57.07; H, 5.54; N, 8.34.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 hours
  3. temperatureAfter the reaction mixture was cooled
  4. extractionthe resulting mixture was extracted with methylene chloride
  5. washThe organic layer was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-05a75eb72c374d90b063afae6d5f8dbf
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509361B1

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