4-(4-Chlorophenyl)-1-[3-(5,11-dihydro-7-hydroxy [1]benzoxepino [2,3-b]pyridin-5-ylidene)propyl]piperidin-4-ol → 5-Chloro-1'-[3-(5,11-dihydro-7-(2-methoxyethyl)oxy[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]spiro[isobenzofuran-1 (3H), 4'-piperidine]
반응식
ClC1C=CC(C2(O)CCN(CCC=C3C4[C:22](=NC=CC=4)[O:21][C:20]4C=CC=C(O)[C:19]=4C3)CC2)=CC=1.[Cl:34][C:35]1[CH:36]=[C:37]2[C:65](=[CH:66][CH:67]=1)[C:40]1([CH2:45][CH2:44][N:43]([CH2:46][CH2:47][CH:48]=[C:49]3[C:59]4[C:54](=[N:55][CH:56]=[CH:57][CH:58]=4)[O:53][C:52]4[CH:60]=[CH:61][CH:62]=[C:63]([OH:64])[C:51]=4[CH2:50]3)[CH2:42][CH2:41]1)[O:39][CH2:38]2>>[Cl:34][C:35]1[CH:36]=[C:37]2[C:65](=[CH:66][CH:67]=1)[C:40]1([CH2:41][CH2:42][N:43]([CH2:46][CH2:47][CH:48]=[C:49]3[C:59]4[C:54](=[N:55][CH:56]=[CH:57][CH:58]=4)[O:53][C:52]4[CH:60]=[CH:61][CH:62]=[C:63]([O:64][CH2:19][CH2:20][O:21][CH3:22])[C:51]=4[CH2:50]3)[CH2:44][CH2:45]1)[O:39][CH2:38]2참가 물질
3
반응물 2
생성물 1
실험 절차
The titled compound was prepared by following the procedure of example 175, but replacing the product of example 44 with the product of example 196.