Methyl 4-(2-oxopyrrolidin-1-yl)benzoate → 1-(4-Methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one

HRID 1635552노트

반응식

HRID 1635552 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[CH:7][CH:6]=1)=[O:4].F[B-](F)(F)F.[O:22]=[N+:23]=[O:24]>ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[C:9]([N+:23]([O-:24])=[O:22])[CH:10]=1)=[O:4]

참가 물질

4

반응물 2

HCID 757827Methyl 4-(2-oxopyrrolidin-1-yl)benzoateHCID 11073463Nitronium tetrafluoroborate

생성물 1

HCID 106830071-(4-Methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
10 °C

실험 절차

An ice-cold mixture of the above ester (2.0 g, 9.1 mmol) in 30 mL of dichloromethane was treated with nitronium tetrafluoroborate (2.5 g, 18.8 mmol). The resulting mixture was stirred at 10° C. for 2 h and then at ambient temperature for 4 h. The reaction mixture was quenched with water (20 mL) and the organic layer was evaporated under vacuum. The white solid precipitate was collected by filtration, washed with water and dried to give 2.2 g (92%) of 1-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one, mp 159-161° C. (chloroforn/ether).

후처리

  1. waitat ambient temperature for 4 h
  2. customThe reaction mixture was quenched with water (20 mL)
  3. customthe organic layer was evaporated under vacuum
  4. filtrationThe white solid precipitate was collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-9ec9cb610b734f5b982a2c9f3c33e673
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509359B1

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