Thionyl Chloride → HCID 12011185, 화합물

HRID 1635575노트

반응식

S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16]O>>[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16][Cl:3]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 12011184HCID 12011184, 화합물

생성물 1

HCID 12011185HCID 12011185, 화합물

반응 조건

온도: 50 °C

실험 절차

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1-(2′-chlorobenzyl)-4,5-dimethyl-2-hydroxymethyl-imidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl chloride is evaporated in vacuo. The residue is dissolved in 10 ml of dichloromethane, then evaporated in vacuo. This is repeated twice to give 1-(2′-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole as a cream colored foam which is used in next step without further purification.

후처리

customthe thionyl chloride is evaporated in vacuo
dissolutionThe residue is dissolved in 10 ml of dichloromethane
customevaporated in vacuo

출처 및 근거

ORD 기록: ord-6e8114d43c824ef5bd49c1e52ae14c53
출처 데이터셋: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06509366B2

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