Oxalyl chloride → 4-(4-Methyl-1H-imidazol-1-yl)benzoyl chloride
반응식
[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:7]2[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][CH:8]=2)[CH:6]=1.C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C)C=O>[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([Cl:19])=[O:12])=[CH:9][CH:8]=2)[CH:6]=1참가 물질
5
실험 절차
To a suspension of 4-(4-methylimidazol-1-yl)benzoic acid (0.80 g) in dichloromethane (25 ml) was added oxalyl chloride (0.50 g) and one drop of dimethylformamide. The mixture was stirred at room temperature for 18 hours and the volatile material was removed under reduced pressure to yield 4-(4-methylimidazol-1-yl)benzoyl chloride (1.02 g), which was utilized without further purification.
후처리
- customthe volatile material was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-68d696495d0145908b0605b4b9fba5f5
- 출처 데이터셋
- uspto-grants-2003_01
- 특허 번호
- US06511974B1
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