Nitric Acid → 2-Chloro-6-fluoro-3-nitrobenzeneacetic acid

HRID 1635923

반응식

HRID 1635923 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]([OH:12])=[O:11].S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>>[Cl:1][C:2]1[C:7]([N+:18]([O-:20])=[O:19])=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]([OH:12])=[O:11]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 1234642-Chloro-6-fluorophenylacetic acid

생성물 1

HCID 696933382-Chloro-6-fluoro-3-nitrobenzeneacetic acid수율 78%

실험 절차

1.89 g of 2-chloro-6-fluoro-phenylacetic acid was suspended in 20 ml of concentrated nitric acid. After the addition of 10 ml of concentrated sulfuric acid, the resulting mixture was heated under reflux for 3.5 hours. After the reaction mixture was poured into ice water, the resulting precipitate was collected by filtration, washed with a small amount of purified water, and then dried. Thus, 1.83 g (78% yield) of the title compound was obtained as a white powder.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 3.5 hours
  3. filtrationthe resulting precipitate was collected by filtration
  4. washwashed with a small amount of purified water
  5. customdried

출처 및 근거

ORD 기록
ord-62993e7f5fc24a7da8ff2c1508456f84
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06511997B1

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