HCID 86586541, 화합물 → HCID 10156794, 화합물

HRID 1636065노트

반응식

HRID 1636065 반응식
C([O:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1

참가 물질

4

반응물 1

HCID 86586541HCID 86586541, 화합물

생성물 1

HCID 10156794HCID 10156794, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

400 mg (0.845 mmol) 8-(11-Oxo-6,11-dihydro-dibenzo[b,e]oxepin-2 yloxy)-octanoic acid benzyloxyamide in 50 ml methanol was hydrogenated in the presence of palladium on calcium carbonate at ambient temperature and pressure. The catalyst was removed by filtration and the solvent was evaporated. The residue was purified by column chromatography (methanol/water 75:25). There was thus obtained 90 mg (28%) of the title compound as an amorphous solid. MS: 382 (M−H+); 384 (M+H+).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated
  3. customThe residue was purified by column chromatography (methanol/water 75:25)

출처 및 근거

ORD 기록
ord-9450982f2fc1429b88f10c77f65d4f73
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06512123B2

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