참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nefazodone | HCID 4449 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Nefazodone Hydrochloride | HCID 54911 | — |
반응 단계
Nefazodone HCl was prepared in accordance with Example 2 of U.S. Pat. No. 4,338,317. Nefazodone HCI was dissolved in water with gentle heating (40-45° C.). An equimolar quantity of sodium hydroxide solution (0.1 N) was added with constant stirring while cooling with ice. Nefazodone base precipitated as a sticky gum which was separated and washed repeatedly with water. The base was washed with water until no chloride ions (AgNO3 test) were detected in the washings. Nefazodone base was then dissolved and crystallized from isopropyl alcohol (IPA) to give a solid melting 81-83° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06034085 |
|---|
| 출처 데이터셋 | uspto-grants-2000_03 |
|---|
| ORD ID | ord-02174f92564844058b99dde18f2e5844 |
|---|
| 출처 메모 | uspto-grants-2000_03 |
|---|
