Tetrahydrofuran → 1-Benzyl-4-[2-(trifluoromethyl)phenyl]piperidin-4-ol
반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[CH2:12]([N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C:20]1=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[Cl-].[NH4+].C1C[O:31]CC1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([OH:31])([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8]([F:11])([F:10])[F:9])[CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1참가 물질
실험 절차
3.25 g (0.135 mol) of Mg are mixed with a spatula tipfull of 12, and a solution of 30.4 g (0.135 mol) of 2-bromo-1-trifluoromethylbenzene in 125 ml of THF is added dropwise. The mixture is stirred for one hour at room temperature and 10.1 g (0.041 mol) of benzylpiperidone are added dropwise. The mixture is stirred for 1 hour at room temperature and a saturated ammonium chloride solution is added. After extraction with ethyl ether, the organic phase is dried and the solvent is evaporated off under reduced pressure. The product is purified by chromatography on a silica gel column using a cyclohexane/ethyl acetate mixture as the eluent to give 6.8 g of 1-benzyl-4-hydroxy-4-(2-tri-fluoromethylphenyl)piperidine, which is hydrogenated with 0.7 g of 10% Pd/C in 75 ml of 95% ethanol which has been brought to acid pH by the addition of hydrochloric acid, the mixture being heated at a temperature of 60° C. for 8 hours. The catalyst is filtered off to give 2.1 g of the title product M.p. 247-251° C.
후처리
- stirringThe mixture is stirred for 1 hour at room temperature
- extractionAfter extraction with ethyl ether
- customthe organic phase is dried
- customthe solvent is evaporated off under reduced pressure
- customThe product is purified by chromatography on a silica gel column
출처 및 근거
- ORD 기록
- ord-45dabb6a98884537888e3d20091dd185
- 출처 데이터셋
- uspto-grants-2000_03
- 특허 번호
- US06034090
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