Acetic Acid → 4-[(2-methoxyanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one

HRID 1636335

반응식

HRID 1636335 반응식
[CH3:1][C:2]1[CH2:3][C:4](=[O:13])[N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH3:14][O:15][C:16]1[C:17]([NH2:22])=[CH:18][CH:19]=[CH:20][CH:21]=1.[C:23](O)(=O)C>CO>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[NH:22][CH:23]=[C:3]1[C:2]([CH3:1])=[N:6][N:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:4]1=[O:13]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 4021Mci-186HCID 70002-Methoxyaniline

생성물 1

HCID 1784895884-[(2-methoxyanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-Methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 2 g trimethylorthoformiate (188 ml) and o-anisidin (1.29 ml) are heated swith glacial acetic acid (5 ml) to 70° C. for 2 hours. After the reaction mixture cools down, methanol is added. The precipitate is collected and recrystallized in ethylacetate.

후처리

  1. customThe precipitate is collected
  2. customrecrystallized in ethylacetate

출처 및 근거

ORD 기록
ord-a1630f581d4c42ee937e13720b101adb
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034099

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