Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine chloride → 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine chloride | HCID 24640 | — |
| 반응물 | 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline | HCID 391870 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole | HCID 10068437 | 56.1% |
반응 단계
2-(4'-Aminophenyl)-6-methoxybenzothiazole (0.22 g, 0.84 mmol) was treated with iodine monochloride (0.21 g, 1.3 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel, using ethyl acetate-hexane (1:3) as eluent, to give brown small crystals (0.18 g, 54.9%), m.p. 179.2-181.1° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06034246 |
| 출처 데이터셋 | uspto-grants-2000_03 |
| ORD ID | ord-06fc31bab1024d1a891d176b03be7e52 |
| 출처 메모 | uspto-grants-2000_03 |