Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine chloride → 2-(4'-Amino-3'-iodophenyl)benzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine chloride | HCID 24640 | — |
| 반응물 | Benzenamine, 4-(2-benzoxazolyl)- | HCID 88733 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-(4'-Amino-3'-iodophenyl)benzoxazole | HCID 10664560 | 65.8% |
반응 단계
2-(4'-Aminophenyl)benzoxazole (0.14 g, 1.9 mmol) was treated with iodine monochloride (0.37 g, 2.23 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel using ethyl acetate-hexane (1:2) as eluent to give a brown powder (0.42 g, 65.7%), m.p. 188.0-191.2° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06034246 |
| 출처 데이터셋 | uspto-grants-2000_03 |
| ORD ID | ord-a07fadc62b394afeb50f1cdbfe96ed79 |
| 출처 메모 | uspto-grants-2000_03 |