2-(4-Aminophenyl)-6-methylbenzothiazole → 2-Bromo-4-(6-methyl-2-benzothiazolyl)benzenamine

HRID 1636557노트

반응식

HRID 1636557 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[Br:18]Br>ClCCl>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:7]=1[Br:18]

참가 물질

4

반응물 2

HCID 70872-(4-Aminophenyl)-6-methylbenzothiazoleHCID 24408Bromine

생성물 1

HCID 3879492-Bromo-4-(6-methyl-2-benzothiazolyl)benzenamine수율 85.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-(4'-Aminophenyl)-6-methylbenzothiazole (0.6 g, 2.5 mmol) was treated with bromine (0.403 g, 2.5 mmol) in dichloromethane according to the above-described general procedure for bromination. Crude product was purified by flash chromatography on silica gel, using ethyl acetate-hexane (1:3) as eluent, to give brown small crystals (0.68 g, 85.3%), m.p. 187.9-189.5° C.

후처리

  1. customCrude product was purified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-3ebd9a092d444e0db1f15463225f7f7f
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034246

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