Benzenamine, 4-(2-benzothiazolyl)-2-iodo- → 2-(4-Amino-3-cyanophenyl)benzothiazole

HRID 1636558

반응식

HRID 1636558 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1I.[Cu][C:19]#[N:20].NC1C=CC(C2SC3C=CC=CC=3N=2)=CC=1Cl>CN(C=O)C>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1[C:19]#[N:20]

참가 물질

5

반응물 3

HCID 384526Benzenamine, 4-(2-benzothiazolyl)-2-iodo-HCID 3879504-(2-Benzothiazolyl)-2-chloro-benzenamineHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 105148972-(4-Amino-3-cyanophenyl)benzothiazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-(4'-amino-3'-iodophenyl)benzothiazole (0.123 g, 0.35 mmol) was treated with copper (I) cyanide (63 mg, 0.7 mmol) in DMF according to procedure for preparation of 2-(4'-amino-3'-chlorophenyl) benzothiazole. The crude product was purified by chromatography on silica gel, eluting with ethyl acetate-hexane (2:3) to give a pale yellow powder (0.032 g, 36%%), m.p. 207.3-211.0° C.

후처리

  1. customThe crude product was purified by chromatography on silica gel
  2. washeluting with ethyl acetate-hexane (2:3)
  3. customto give a pale yellow powder (0.032 g, 36%%), m.p. 207.3-211.0° C.

출처 및 근거

ORD 기록
ord-fb8d2ea72f0449f08345ff284ecb9fdf
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034246

연결된 노트

불러오는 중…