Sodium Carbonate → Sodium 4-(benzothiazol-2-yl)-3-methylphenylsulphamate

HRID 1636569

반응식

HRID 1636569 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1C.Cl[S:19]([OH:22])(=[O:21])=[O:20].S(=O)(=O)([O-])N.[C:28](=O)([O-])[O-].[Na+:32].[Na+]>N1C=CC=CC=1C>[S:9]1[C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=[C:8]1[C:5]1[CH:4]=[CH:3][C:2]([NH:1][S:19](=[O:20])(=[O:21])[O-:22])=[CH:7][C:6]=1[CH3:28].[Na+:32]

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 24638Chlorosulfonic acidHCID 177700Sulfamate ionHCID 3845254-(1,3-Benzothiazol-2-Yl)-2-Methylaniline

생성물 1

HCID 23717893Sodium 4-(benzothiazol-2-yl)-3-methylphenylsulphamate수율 82%

시약·촉매·용매 1

HCID 79752-Methylpyridine용매

실험 절차

2-(4'-amino-3'-methylphenyl)benzothiazole was treated with chlorsulphonic acid in 2-picoline and sodium carbonate according to the above-described general procedure for preparation of sulphamate salts. A yellow powder was obtained in 82% yield, m.p. 169.5° C. (dec).

후처리

  1. customA yellow powder was obtained in 82% yield, m.p. 169.5° C. (dec)

출처 및 근거

ORD 기록
ord-b284a1addd384723abc044f769c917ea
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034246

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