p-Fluoronitrobenzene → 2-(4-Nitrophenyl)-2h-1,2,3-triazole

HRID 1636681노트

반응식

HRID 1636681 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][N:13]=[N:12]1>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:12]2[N:13]=[CH:14][CH:15]=[N:11]2)=[CH:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 9590p-FluoronitrobenzeneHCID 178418936HCID 178418936, 화합물

생성물 1

HCID 2781582-(4-Nitrophenyl)-2h-1,2,3-triazole수율 66.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4-Fluoronitrobenzene (21 g) was reacted with 1H-1,2,3-triazole (12.4 g) in the same manner as in Reference Example 9. The resultant was cooled and poured into water. The precipitated crystals were collected by filtration and purified by silica gel chromatography (eluent:dichloromethane to dichloromethane/acetone=8/1). The first eluted fraction was recrystallized from dichloromethane-diisopropyl ether to give 2-(4-nitrophenyl)-2H-1,2,3-triazole (18.8 g) as pale yellow prisms.

후처리

  1. temperatureThe resultant was cooled
  2. filtrationThe precipitated crystals were collected by filtration
  3. custompurified by silica gel chromatography (eluent:dichloromethane to dichloromethane/acetone=8/1)
  4. customThe first eluted fraction was recrystallized from dichloromethane-diisopropyl ether

출처 및 근거

ORD 기록
ord-805aa0a200f940a584a03de107af81d5
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034248

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