HCID 21996968, 화합물 → HCID 21996988, 화합물

반응식

BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[CH:20]=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]

참가 물질

반응물 2

HCID 21996968HCID 21996968, 화합물2회

HCID 21996975HCID 21996975, 화합물2회

생성물 1

HCID 21996988HCID 21996988, 화합물

실험 절차

Employing the same general procedure as for the preparation 5-bromo-2-hydroxy-4'-methylbenzophenone (Compound K), 533 mg (1.7 mmol) of 5-bromo-2-methoxy-3'-methylbenzophenone (Compound J) was converted into the title compound using 2.6 mL (2.6 mmol) of boron tribromide (1M in dichloromethane) and 15 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.

출처 및 근거

ORD 기록: ord-bfab717976864e4686e7160a2d759afd
출처 데이터셋: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06037488

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