((Nitroveratryl)oxy)chlorocarbamate → 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-((4,5-dimethoxy-2-nitrobenzyloxy)carbonyl)hydrazine

HRID 1637391노트

반응식

HRID 1637391 반응식
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[CH:8][C:7]=1[N+:16]([O-:18])=[O:17])=[O:3].[CH3:19][S:20]([N:23]([CH2:38][CH2:39][Cl:40])[N:24]([S:34]([CH3:37])(=[O:36])=[O:35])C(OC1C=CC=CC=1)=O)(=[O:22])=[O:21]>>[CH3:19][S:20]([N:23]([CH2:38][CH2:39][Cl:40])[N:24]([S:34]([CH3:37])(=[O:36])=[O:35])[C:2]([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[CH:8][C:7]=1[N+:16]([O-:18])=[O:17])=[O:3])(=[O:21])=[O:22]

참가 물질

3

반응물 2

HCID 3084878((Nitroveratryl)oxy)chlorocarbamateHCID 97995471,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(phenoxycarbonyl)hydrazine

생성물 1

HCID 99352871,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-((4,5-dimethoxy-2-nitrobenzyloxy)carbonyl)hydrazine

실험 절차

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4,5-dimethoxy-2-nitrobenzyloxy)carbonyl]hydrazine (compound 12) was prepared by reacting 4,5-dimethoxy-2-nitrobenzyl chloroformate with compound 2 using a procedure similar to that described for compound 10d. The product was recrystallized from ethanol, and the Mp was about 154° C. Yield was about 17.6% by weight. 1H NMR (acetone d6): δ 7.7 and 7.4 (2H, 2s, aromatic H), 5.8 (2H, d, ArCH2), 3.7-4.1 (4H, m, CH2CH2Cl), 3.9-4.0 (6H, 2s, 2 OCH3), and 3.5 and 3.2 (6H, 2s, 2 CH3SO2).

후처리

  1. customThe product was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-e761d6f972e745b48d4c603ce317a521
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06040338

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