3-Methoxypropyl 4-methylbenzenesulfonate → 3-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

HRID 1637539노트

반응식

HRID 1637539 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12]C)=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1.[CH3:20][O:21][CH2:22][CH2:23][CH2:24]OS(C1C=CC(C)=CC=1)(=O)=O>CCOCC>[CH3:20][O:21][CH2:22][CH2:23][CH2:24][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([OH:12])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1

참가 물질

4

반응물 2

HCID 135229883-Methoxypropyl 4-methylbenzenesulfonateHCID 19348616Methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate

생성물 1

HCID 193487163-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate (prepared as described in Preparation 58A), and 3-methoxy-1-tosyloxypropane, the corresponding ether derivative was obtained. Hydrolysis of this derivative and subsequent treatment of the reaction mixture were conducted in a similar manner to that described in Preparation 7 to give the title compound as an oily substance.

후처리

  1. customthat described in Preparation 45A(i)
  2. customHydrolysis of this derivative and subsequent treatment of the reaction mixture
  3. customdescribed in Preparation 7

출처 및 근거

ORD 기록
ord-add7bf2443204833ab1e8db175d04258
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06040339

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